2013 Course Description
- June 12, Wednesday afternoon
The Optics of Turbid Tissue, Prof. Andrew Berger (Rochester):
Photon transport in biological tissues can often be modeled with the mathematics of diffusion. In this lecture, the steady-state, time- and frequency-domain representations of optical diffusion theory will be introduced along with the general conditions under which these treatments are valid. We will review the principal near-infrared absorbers and scatterers in a variety of soft tissues, emphasizing on those tissues, geometries and wavelength regions in which optical diffusion may be exploited. In addition, we will consider applications of diffusion theory to spectroscopy and tomorgraphic imaging of the breast and brain, with an emphasis on the various chromphores and scatterers that can be characterized via noninvasive spectroscopic techniques.
- June 13, Thursday morning
Instrumentations and Clinical Applications of Diffuse Optics, Prof. Regine Choe (Rochester):
Diffuse optical techniques have a great potential for detection and monitoring of disease, since they provide functional and physiological information non-invasively. Furthermore, the use of non- ionizing radiation and technologically simple, fast, inexpensive instrumentation makes diffuse optics attractive for translational research. This lecture will focus on the instrumentation design consideration and clinical applications of diffuse optics in rain, breast and muscle.
- June 13, Thursday afternoon
The Optics of Watching Live Cells, Prof. Edward Brown (Rochester):
A large fraction of biological advances in the modern era have depended upon the visualization of living cells, or intact tissues, using light microscopy. This lecture will cover the principles and practices behind the major types of light microscopes that are most used in the modern laboratory, including the basic compound microscope with Kohler illumination, epifluorescence microscopy, confocal laser-scanning microscopy, and multiphoton laser-scanning microscopy. In addition, the basic concepts of aberration and resolution that are required to utilize these technologies in the biological laboratory will be covered. The objective of this lecture is to enable the audience member to choose the right type of microscope for their biological application, use the microscope properly, understand its principles, and be able to modify the system to perform new functions.
- June 14, Friday morning
Spectroscopic Monitoring and Diagnostics, Prof. Andrew Berger (Rochester):
This lecture will cover optically-based spectroscopic sensing and diagnostic modalities for biomedical applications. The lecture will primarily cover four optical modalities: infrared absorption, Raman spectroscopy, fluorescence spectroscopy, and elastic light scattering. The overall objective of the lecture is to enable the participant to compare and contrast these four fundamental optical approaches for biomedical sensing and diagnostic applications.
- June 15, Friday afternoon
Optics and the Eye, Prof. Jennifer Hunter (Rochester):
The Optics of High Resolution Retinal Imaging - Adaptive optics, first developed for astronomical telescopes, has made it possible to resolve individual cells, such as rods and cones, at the back of the living eye. Recently, adaptive optics has begun to be applied to microscopy in general. In the eye, images are obtained using scanning laser ophthalmoscopes that use the optics of the eye in place of a microscope objective. This session will discuss the principles of retinal imaging , ocular wavefront sensing and adaptive optics.